Based on data from 30 vehicles, 2,338 fuel-ups and 617,178 miles of driving, the 2006 Lexus IS350 gets a combined Avg MPG of 21.31 with a 0.17 MPG margin of error.

Any Engine Type 3.5L V6 GAS (27) V6 GAS (2) Any Body Style Sedan (7) Any Submodel Base (27) Other (3)

Below you can see a distribution of the fuel-ups with 64 outliers (2.66%) removed.

Following shows the average MPG of each of the 30 vehicles in the system.

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• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Mar 2025 • 27 Fuel-ups

  Property of LucasG5215

• 21.9 Avg MPG

• Lexus IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed Sedan
  Added Feb 2020 • 121 Fuel-ups

  Property of Chris396

• 24.0 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Apr 2025 • 4 Fuel-ups

  Property of zyfinity

• 16.5 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Mar 2018 • 247 Fuel-ups

  Property of ejung

• 16.8 Avg MPG

• IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Mar 2018 • 33 Fuel-ups

  Property of misofst

• 18.3 Avg MPG

• IS 350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed Sedan
  Added Jun 2021 • 52 Fuel-ups

  Property of A1cntrler

• 24.6 Avg MPG

• IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed Sedan
  Added Dec 2018 • 128 Fuel-ups

  Property of Fauxbias

• 19.2 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Nov 2021 • 31 Fuel-ups

  Property of BarbaraGo

• 23.6 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Mar 2024 • 9 Fuel-ups

  Property of DigginYou23

• 24.7 Avg MPG

• Frank’s IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Jul 2024 • 10 Fuel-ups

  Property of FrankRozay

• 18.8 Avg MPG

• Lexus IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Jun 2011 • 200 Fuel-ups

  Property of thisisyourlife

• 17.8 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Mar 2024 • 14 Fuel-ups

  Property of emmais350

• 16.4 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Sep 2021 • 75 Fuel-ups

  Property of lilyann

• 21.0 Avg MPG

• IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Apr 2017 • 201 Fuel-ups

  Property of kalohe2

• 28.1 Avg MPG

• Tree Fiddy

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed Sedan
  Added Feb 2019 • 86 Fuel-ups

  Property of Canuckrz

• 23.9 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Apr 2018 • 150 Fuel-ups

  Property of mikelnohands

• 19.3 Avg MPG

• Hak's IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Aug 2016 • 587 Fuel-ups

  Property of hybridanime

• 23.4 Avg MPG

• Lexus

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed Sedan
  Added Nov 2018 • 34 Fuel-ups

  Property of Carboi91

• 24.5 Avg MPG

• My IS350

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Aug 2018 • 33 Fuel-ups

  Property of criticman

• 20.2 Avg MPG

• Lexus

  2006 Lexus IS350 3.5L V6 GAS Automatic 6 Speed
  Added Mar 2017 • 158 Fuel-ups

  Property of lisachristine13

• 22.3 Avg MPG

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