Based on data from 40 vehicles, 2,655 fuel-ups and 843,228 miles of driving, the 2010 Mercedes-Benz E350 gets a combined Avg MPG of 20.88 with a 0.14 MPG margin of error.

Any Engine Type 3.5L V6 GAS (31) V6 DIESEL (1) V6 GAS (4) Any Body Style Sedan (9) Hatchback (1) Any Submodel Elegance (2) Base (3) Sport (5) 4Matic (22) Other (8)

Below you can see a distribution of the fuel-ups with 152 outliers (5.42%) removed.

Following shows the average MPG of each of the 40 vehicles in the system.

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• My E350

  2010 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Apr 2018 • 11 Fuel-ups

  Property of Dr0n3

• 17.9 Avg MPG

• Bennie

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2017 • 7 Fuel-ups

  Property of mnm2124

• 23.0 Avg MPG

• My E350

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2017 • 5 Fuel-ups

  Property of Skally6

• 14.7 Avg MPG

• MB2

  2010 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Jan 2016 • 40 Fuel-ups

  Property of Abmd

• 24.4 Avg MPG

• W212

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Jan 2018 • 11 Fuel-ups

  Property of Jays964

• 23.1 Avg MPG

• My E350

  2010 Mercedes-Benz E350 4Matic
  Added May 2016 • 10 Fuel-ups

  Property of fajtruth

• 17.9 Avg MPG

• E-350

  2010 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Sedan (4 Door)
  Added Jun 2015 • 20 Fuel-ups

  Property of mac46

• 23.3 Avg MPG

• My Merc

  2010 Mercedes-Benz E350 Coupe
  Added Aug 2016 • 109 Fuel-ups

  Property of hgdnod

• 17.1 Avg MPG

• E350-4M

  2010 Mercedes-Benz E350
  Added Jan 2013 • 45 Fuel-ups

  Property of mbuster25

• 23.9 Avg MPG

• Mercedes Benz

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2018 • 52 Fuel-ups

  Property of dcatkc

• 23.2 Avg MPG

• E350 Coupe

  2010 Mercedes-Benz E350 GAS V6
  Added Jan 2014 • 9 Fuel-ups

  Property of AwieT

• 19.6 Avg MPG

• E350 CDI

  2010 Mercedes-Benz E350 DIESEL V6
  Added Nov 2012 • 18 Fuel-ups

  Property of tvildo

• 19.6 Avg MPG

• Mercedes

  2010 Mercedes-Benz E350 Bluetec
  Added Nov 2016 • 85 Fuel-ups

  Property of jafomct

• 30.9 Avg MPG

• E350

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2017 • 4 Fuel-ups

  Property of BizzyDaKid

• 18.7 Avg MPG

• Carla (W212)

  2010 Mercedes-Benz E350 GAS V6
  Added Feb 2012 • 13 Fuel-ups

  Property of zmp

• 20.4 Avg MPG

• Merc E350C

  2010 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2017 • 42 Fuel-ups

  Property of xs2xa

• 20.1 Avg MPG

• E350 4Matic

  2010 Mercedes-Benz E350 GAS V6
  Added Apr 2011 • 20 Fuel-ups

  Property of Repmanhill

• 21.3 Avg MPG

• Mercedes

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2016 • 75 Fuel-ups

  Property of dougeinraleigh

• 23.8 Avg MPG

• Merc

  2010 Mercedes-Benz E350 GAS V6
  Added Aug 2009 • 26 Fuel-ups

  Property of Ductor

• 22.4 Avg MPG

• E350 Coupe

  2010 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2016 • 15 Fuel-ups

  Property of oneroad

• 6.6 Avg MPG

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