Based on data from 29 vehicles, 2,819 fuel-ups and 844,955 miles of driving, the 2008 Mercedes-Benz E350 gets a combined Avg MPG of 20.09 with a 0.11 MPG margin of error.

Any Engine Type 3.5L V6 GAS (25) V6 GAS (4) Any Body Style Sedan (4) Any Submodel Elegance (2) Base (4) Sport (8) 4Matic (11) Other (4)

Below you can see a distribution of the fuel-ups with 283 outliers (9.12%) removed.

Following shows the average MPG of each of the 29 vehicles in the system.

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• My E350 Feb 2014 21.1

  2008 Mercedes-Benz E350 Elegance 3.5L V6 GAS Automatic 7 Speed
  Added Apr 2024 • 48 Fuel-ups

  Property of afeuerb

• 23.5 Avg MPG

• MB E350

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed Sedan
  Added Jan 2025 • 346 Fuel-ups

  Property of n1ckj

• 21.1 Avg MPG

• Circle Car II

  2008 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Sep 2014 • 93 Fuel-ups

  Property of fmeckling

• 16.2 Avg MPG

• My E350

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Jul 2024 • 11 Fuel-ups

  Property of xevilpetex

• 15.9 Avg MPG

• Mercedes E350

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Feb 2018 • 143 Fuel-ups

  Property of splee

• 16.8 Avg MPG

• Mercedes E350

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Jun 2019 • 83 Fuel-ups

  Property of csaliture

• 20.3 Avg MPG

• My E350

  2008 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2020 • 35 Fuel-ups

  Property of cpellatz

• 22.4 Avg MPG

• Peanut Butter (E350)

  2008 Mercedes-Benz E350 Elegance 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Jun 2018 • 50 Fuel-ups

  Property of dennisoriley

• 22.5 Avg MPG

• My E350

  2008 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2018 • 8 Fuel-ups

  Property of sgfc

• 21.4 Avg MPG

• E-350

  2008 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2016 • 49 Fuel-ups

  Property of jeoffinsb

• 14.9 Avg MPG

• Mercedes E350

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Sep 2016 • 258 Fuel-ups

  Property of xenaxw

• 21.7 Avg MPG

• Art Artiles

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed Sedan
  Added Apr 2018 • 686 Fuel-ups

  Property of aartiles

• 21.2 Avg MPG

• Archive - Mercedes E350 (2008)

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Feb 2018 • 21 Fuel-ups

  Property of albertsempire

• 18.2 Avg MPG

• E350 Mercedes

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Aug 2016 • 85 Fuel-ups

  Property of mcrow1990

• 20.7 Avg MPG

• 2008 E350

  2008 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2018 • 12 Fuel-ups

  Property of bmw04e46

• 17.5 Avg MPG

• Mercedes

  2008 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2016 • 212 Fuel-ups

  Property of auger

• 18.8 Avg MPG

• MB E350

  2008 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Sedan (4 Door)
  Added Oct 2013 • 66 Fuel-ups

  Property of Rotnase

• 19.6 Avg MPG

• Mercedes

  2008 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Oct 2016 • 166 Fuel-ups

  Property of auger

• 20.8 Avg MPG

• Mercedes

  2008 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2016 • 163 Fuel-ups

  Property of auger

• 19.5 Avg MPG

• Mercedes

  2008 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed
  Added Oct 2016 • 180 Fuel-ups

  Property of auger

• 19.3 Avg MPG

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