Based on data from 26 vehicles, 2,240 fuel-ups and 657,580 miles of driving, the 2006 Mercedes-Benz E350 gets a combined Avg MPG of 19.02 with a 0.16 MPG margin of error.

Any Engine Type 3.5L V6 GAS (24) V6 GAS (1) Any Body Style Sedan (5) Wagon (1) Any Submodel Sport (2) Base (11) 4Matic (11) Other (2)

Below you can see a distribution of the fuel-ups with 72 outliers (3.11%) removed.

Following shows the average MPG of each of the 26 vehicles in the system.

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• E350

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Jan 2022 • 129 Fuel-ups

  Property of wolffullmoon

• 20.4 Avg MPG

• Mercedes E350

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2016 • 362 Fuel-ups

  Property of Kawika858

• 22.3 Avg MPG

• Benz

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Dec 2022 • 129 Fuel-ups

  Property of PetePostas

• 19.8 Avg MPG

• Mercedes Benz

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added May 2016 • 275 Fuel-ups

  Property of rb_ranch

• 21.6 Avg MPG

• Erma

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Jun 2022 • 41 Fuel-ups

  Property of ninja4

• 20.4 Avg MPG

• e350

  2006 Mercedes-Benz E350 Sport 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Feb 2018 • 83 Fuel-ups

  Property of jasonkung

• 16.6 Avg MPG

• My E350

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Oct 2019 • 126 Fuel-ups

  Property of jdude

• 18.0 Avg MPG

• Oscar

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Mar 2017 • 73 Fuel-ups

  Property of dru1

• 19.0 Avg MPG

• E350

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2016 • 215 Fuel-ups

  Property of teddyf

• 16.2 Avg MPG

• Mercedes E350

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Mar 2017 • 98 Fuel-ups

  Property of forjrf

• 19.2 Avg MPG

• Mercedes

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Apr 2017 • 182 Fuel-ups

  Property of daoneill

• 18.3 Avg MPG

• Jaz-E350

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Aug 2018 • 43 Fuel-ups

  Property of mrkevinhoang

• 18.3 Avg MPG

• My E350

  2006 Mercedes-Benz E350 4Matic 3,5L V6 GAS Automatic 5 Speed
  Added Oct 2016 • 100 Fuel-ups

  Property of iCharlie

• 18.2 Avg MPG

• Sonia

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed
  Added Dec 2018 • 44 Fuel-ups

  Property of Daffodil

• 22.0 Avg MPG

• Mercedes Benz E350 Wagon

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2017 • 46 Fuel-ups

  Property of rkidwell

• 18.3 Avg MPG

• 2006 Mercedes

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed Wagon
  Added Apr 2018 • 71 Fuel-ups

  Property of bariove

• 19.7 Avg MPG

• My E350

  2006 Mercedes-Benz E350 3.5L GAS V6 Automatic 5 Sedan (4 Door)
  Added Sep 2014 • 117 Fuel-ups

  Property of mzz74

• 19.8 Avg MPG

• Benz

  2006 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 5 Speed Sedan
  Added May 2018 • 8 Fuel-ups

  Property of taps442

• 24.5 Avg MPG

• X MB E350 ‘06

  2006 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2018 • 122 Fuel-ups

  Property of stanware

• 20.8 Avg MPG

• Mercedes Benz E350

  2006 Mercedes-Benz E350 Sport 3,5L V6 GAS Automatic 7 Speed Sedan
  Added Feb 2017 • 23 Fuel-ups

  Property of carlitobrigante

• 18.4 Avg MPG

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