Based on data from 35 vehicles, 1,812 fuel-ups and 470,619 miles of driving, the 2021 Lexus RX350 gets a combined Avg MPG of 20.09 with a 0.17 MPG margin of error.

Any Engine Type 3.5L V6 GAS (35) Any Body Style Sport Utility (11) Any Submodel F Sport (3) Base (32)

Below you can see a distribution of the fuel-ups with 76 outliers (4.03%) removed.

Following shows the average MPG of each of the 35 vehicles in the system.

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• My RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Aug 2024 • 39 Fuel-ups

  Property of Ehaq35

• 20.6 Avg MPG

• Jelly Green

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed Sport Utility
  Added Jan 2021 • 101 Fuel-ups

  Property of deanbrew

• 22.2 Avg MPG

• Lexus

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed Sport Utility
  Added Mar 2025 • 9 Fuel-ups

  Property of hamilton

• 20.1 Avg MPG

• My Lexus RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Aug 2021 • 86 Fuel-ups

  Property of kcguy

• 20.5 Avg MPG

• 2021 Lexus RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Dec 2024 • 14 Fuel-ups

  Property of danguy2

• 20.2 Avg MPG

• Joe's RX

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed Sport Utility
  Added Dec 2024 • 10 Fuel-ups

  Property of joburg

• 18.2 Avg MPG

• 2021 Lexus RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Aug 2024 • 23 Fuel-ups

  Property of joey1811

• 16.5 Avg MPG

• Rx350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed Sport Utility
  Added Jun 2024 • 139 Fuel-ups

  Property of joefong01

• 21.7 Avg MPG

• My RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Mar 2021 • 188 Fuel-ups

  Property of wagnerlover

• 18.9 Avg MPG

• Lexus RX350 21

  2021 Lexus RX350 F Sport 3,5L V6 GAS Automatic 8 Speed Sport Utility
  Added Oct 2024 • 31 Fuel-ups

  Property of albielab

• 20.9 Avg MPG

• Lexus RX 350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Apr 2021 • 94 Fuel-ups

  Property of rklingler

• 17.6 Avg MPG

• My RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Jun 2021 • 153 Fuel-ups

  Property of nbabin

• 26.1 Avg MPG

• Moon Unit

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed Sport Utility
  Added Mar 2025 • 5 Fuel-ups

  Property of ddmau

• 22.7 Avg MPG

• Our RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Feb 2025 • 3 Fuel-ups

  Property of dbazzett

• 21.4 Avg MPG

• Lexus RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Feb 2024 • 40 Fuel-ups

  Property of jmaner89

• 26.0 Avg MPG

• 21 RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Apr 2024 • 37 Fuel-ups

  Property of pcwhitmire

• 23.2 Avg MPG

• RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Feb 2021 • 74 Fuel-ups

  Property of Michael823

• 19.5 Avg MPG

• OLD-Lexus RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed Sport Utility
  Added Feb 2021 • 81 Fuel-ups

  Property of vwsport

• 26.3 Avg MPG

• zz 2021 Lexus RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Aug 2021 • 74 Fuel-ups

  Property of acornprod

• 18.4 Avg MPG

• My RX350

  2021 Lexus RX350 3.5L V6 GAS Automatic 8 Speed
  Added Jul 2023 • 17 Fuel-ups

  Property of cabbrunk

• 18.1 Avg MPG

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